FUNCTIONAL ORTHOLOGY EXPLORER

Explore MCFA genes and pathway modules

Interactively inspect annotation-supported markers, orthogroups, and pathway-rule coverage across curated genomes. Genomic presence is not evidence of expression or demonstrated MCFA production.

Find genomes

Search by organism or versioned assembly accession and open its evidence record.

Filter markers

Focus on a named enzyme marker or MCFA pathway module.

Compare patterns

Expand the heatmap to compare marker copy-number patterns.

Trace evidence

Distinguish annotations, reviewed candidates, and pathway assessments.

Search organismMarkerPathway Complete selected module onlyReset

44 genomes currently visible

Marker copy-number heatmap for filtered organisms

Organism names are shown first; assembly accessions remain available as secondary identifiers. The preview is limited to the first 100 matching genomes.

Organism and assembly	Detected markers	Pathway assessments
Limosilactobacillus panis `GCA_019797825.1`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMMaccB^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 6/8
Limosilactobacillus pontis `GCA_009428965.1`Complete Genome	adhE^HMMhbd^HMMthl^HMM	reversebetaoxidationcore 2/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 0/8
Limosilactobacillus portuensis `GCA_028607025.1`Complete Genome	accA^HMMaccB^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2hbd^HMMthl^HMM	reversebetaoxidationcore 2/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 6/8
Limosilactobacillus reuteri I5007 `GCA_000410995.1`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 5/8
Limosilactobacillus reuteri SD2112 `GCA_000159455.2`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 5/8
Limosilactobacillus reuteri TD1 `GCA_000439275.1`Complete Genome	accA^HMMaccD^HMMadhE^HMMfabI^HMMfabZ^HMMthl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 3/8
Limosilactobacillus reuteri subsp. kinnaridis `GCA_041888795.1`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMMaccB^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 6/8
Limosilactobacillus reuteri subsp. reuteri `GCA_054729175.1`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMMaccB^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 6/8
Limosilactobacillus reuteri subsp. reuteri JCM 1112 `GCA_000010005.1`Complete Genome	accA^HMMaccC^HMMaccD^HMMadhE^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMM×2thl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 5/8
Limosilactobacillus reuteri subsp. suis `GCA_000236455.2`Complete Genome	accB^HMMaccA^HMMaccD^HMMadhE^HMMfabI^HMMfabZ^HMM×2thl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 4/8
Limosilactobacillus vaginalis `GCA_025311515.1`Complete Genome	adhE^HMMhbd^HMMthl^HMM	reversebetaoxidationcore 2/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 0/8
Megasphaera coli `GCA_052147965.1`Complete Genome	etfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMMlctP^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM	reversebetaoxidationcore 2/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera elsdenii `GCA_052399495.1`Complete Genome	coat^HMMetfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMlctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2	reversebetaoxidationcore 1/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera elsdenii 14-14 `GCA_001304715.1`Complete Genome	coat^HMMetfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMlctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2	reversebetaoxidationcore 1/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera elsdenii DSM 20460 `GCA_003010495.1`Complete Genome	coat^HMMetfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMlctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2	reversebetaoxidationcore 1/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera hexanoica `GCA_043520715.1`Complete Genome	etfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMMlctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM	reversebetaoxidationcore 2/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera massiliensis `GCA_020181515.1`Complete Genome	etfB^HMM×2fabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMMlctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2	reversebetaoxidationcore 2/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Megasphaera stantonii `GCA_003367905.1`Complete Genome	accB^HMMaccC^HMMcoat^HMM×2etfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMM×2lctP^HMM×2rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2	reversebetaoxidationcore 2/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Megasphaera sueciensis `GCA_050219315.1`Complete Genome	accC^HMMcoat^HMM×3etfB^HMMfabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMMlctP^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2accB^HMM	reversebetaoxidationcore 2/4bcdetfmodule 1/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Proteiniphilum propionicum `GCA_022267555.1`Complete Genome	fabF^HMMfabG^HMMfabH^HMMfabZ^HMMrnfA^HMM×2rnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMM×2	reversebetaoxidationcore 0/4bcdetfmodule 0/3rnfcomplex 5/6lactateentrysupport 0/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Proteiniphilum sp. LBM24028 `GCA_056629195.1`Complete Genome	accC^HMMfabF^HMMfabG^HMMfabZ^HMMrnfA^HMM×2rnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMM×2accB^HMM	reversebetaoxidationcore 0/4bcdetfmodule 0/3rnfcomplex 5/6lactateentrysupport 0/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 4/8
Pseudoramibacter alactolyticus `GCA_050908235.1`Complete Genome	accA^HMMaccB^HMMaccC^HMMaccD^HMMcrt^HMMetfA^HMMetfB^HMMfabF^HMMfabG^HMMfabZ^HMMlctP^HMMrnfA^HMMrnfB^HMMrnfD^HMMrnfE^HMMrnfG^HMM	reversebetaoxidationcore 1/4bcdetfmodule 2/3rnfcomplex 5/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 6/8
Sporolactobacillus sp. Y61 `GCA_040529185.1`Complete Genome	accA^HMMaccB^HMMaccC^HMMaccD^HMMadhE^HMMcoat^HMMfabD^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMMlctP^HMMldh^HMMthl^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 2/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 7/8
Sporolactobacillus terrae `GCA_019930545.1`Complete Genome	accA^HMMaccB^HMMaccC^HMMaccD^HMMadhE^HMMfabD^HMMfabF^HMMfabG^HMMfabI^HMMfabZ^HMMlctP^HMM	reversebetaoxidationcore 0/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 7/8
Sporomusa acidovorans DSM 3132 `GCA_002257695.2`Complete Genome	accB^HMMaccC^HMM×2adhE^HMMcoat^HMM×2etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMM×2fabG^HMMfabH^HMM×3fabK^HMMfabZ^HMMhbd^HMM×2lctP^HMMldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMbcd^HMM×2	reversebetaoxidationcore 2/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 6/8
Sporomusa aerivorans `GCA_041428895.1`Complete Genome	accB^HMMaccC^HMMcoat^HMM×11etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMM×2fabG^HMMfabK^HMMfabZ^HMMhbd^HMM×2lctP^HMM×2ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×4bcd^HMM×4	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Sporomusa carbonis `GCA_041428575.1`Complete Genome	accB^HMMaccC^HMM×2coat^HMM×2etfA^HMM×3etfB^HMM×3fabD^HMMfabF^HMMfabG^HMMfabH^HMMfabK^HMMfabZ^HMMhbd^HMMlctP^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMbcd^HMM×3	reversebetaoxidationcore 2/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 6/8
Sporomusa intestinalis `GCA_055383785.1`Complete Genome	accB^HMMaccC^HMMcoat^HMM×6etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMM×2lctP^HMM×2ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×3bcd^HMM×4	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Sporomusa malonica `GCA_041428715.1`Complete Genome	accB^HMMaccC^HMMcoat^HMM×8etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMM×2fabG^HMM×2fabH^HMMfabZ^HMMhbd^HMMlctP^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMMbcd^HMM×2	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 6/8
Sporomusa ovata DSM 2662 `GCA_000445445.2`Complete Genome	accB^HMMaccC^HMMetfA^HMM×2etfB^HMM×2fabD^HMMfabF^HMMfabG^HMMfabK^HMMfabZ^HMMlctP^HMM×3rnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMM	reversebetaoxidationcore 0/4bcdetfmodule 2/3rnfcomplex 6/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Sporomusa paucivorans `GCA_041428605.1`Complete Genome	etfA^HMM×6etfB^HMM×6fabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMM×2lctP^HMM×3ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMMbcd^HMM×3	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Sporomusa rhizae `GCA_041428845.1`Complete Genome	coat^HMM×2etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMM×2fabG^HMMfabH^HMMfabK^HMMfabZ^HMM×2hbd^HMM×2lctP^HMMldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMbcd^HMM×5	reversebetaoxidationcore 2/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 4/8
Sporomusa silvacetica DSM 10669 `GCA_002257705.2`Complete Genome	accB^HMMaccC^HMMcoat^HMM×2etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMMfabG^HMMfabK^HMMfabZ^HMMhbd^HMM×4lctP^HMM×2ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×2bcd^HMM×2	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Sporomusa sp. 246TCP1 `GCF_057319775.1`Complete Genome	accB^HMMaccC^HMMfabG^HMMfabZ^HMMlctP^HMM	reversebetaoxidationcore 0/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 4/8
Sporomusa sphaeroides `GCA_051046855.1`Complete Genome	etfA^HMM×6etfB^HMM×6fabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMM×2lctP^HMM×3ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMMbcd^HMM×3	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Sporomusa sphaeroides DSM 2875 `GCA_001941975.2`Complete Genome	bcd^HMM×2etfA^HMM×5etfB^HMM×5fabD^HMMfabF^HMMfabG^HMMfabZ^HMMhbd^HMM×2lctP^HMM×3ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
Sporomusa termitida `GCA_007641255.1`Complete Genome	accB^HMMaccC^HMMcoat^HMM×10etfA^HMM×7etfB^HMM×7fabD^HMMfabF^HMMfabG^HMM×2fabZ^HMMhbd^HMM×2lctP^HMM×2ldh^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMMrnfG^HMMthl^HMM×4bcd^HMM×7	reversebetaoxidationcore 3/4bcdetfmodule 3/3rnfcomplex 6/6lactateentrysupport 2/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 5/8
Thermocaproicibacter melissae `GCA_024498295.1`Complete Genome	accA^HMMaccB^HMMaccC^HMMaccD^HMMcrt^HMMfabF^HMMfabG^HMMfabK^HMMfabZ^HMMldh^HMM	reversebetaoxidationcore 1/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 6/8
[Clostridium] innocuum `GCA_012271835.1`Complete Genome	thl^×2hbdcrtldh^×2accBaccCfabZ	reversebetaoxidationcore 3/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
[Clostridium] innocuum `GCA_012317185.1`Complete Genome	thl^×2hbdcrtldh^×2accBaccCfabZ	reversebetaoxidationcore 3/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
[Clostridium] innocuum `GCA_022845735.1`Complete Genome	thl^×2hbdcrtbcdldh^×2accBaccC	reversebetaoxidationcore 4/4bcdetfmodule 1/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 2/8
[Clostridium] innocuum `GCA_023008265.1`Complete Genome	thl^×2crtldh^×2accBaccCfabZ	reversebetaoxidationcore 2/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
[Clostridium] innocuum `GCA_055814455.1`Complete Genome	thl^×2crtldh^×2accBaccCfabZ	reversebetaoxidationcore 2/4bcdetfmodule 0/3rnfcomplex 0/6lactateentrysupport 1/2ethanolentrysupport 0/1fattyacidbiosynthesiscore 3/8
[Clostridium] saccharolyticum WM1 `GCA_000144625.1`Complete Genome	accB^HMMaccD^HMMadhE^HMMetfA^HMMetfB^HMM×2fabD^HMMfabF^HMMfabG^HMMfabK^HMMfabZ^HMMrnfA^HMMrnfB^HMMrnfC^HMMrnfD^HMMrnfE^HMM	reversebetaoxidationcore 0/4bcdetfmodule 2/3rnfcomplex 5/6lactateentrysupport 0/2ethanolentrysupport 1/1fattyacidbiosynthesiscore 5/8

Marker-linked orthogroups and proteins

Enter a marker gene to narrow the orthogroup menu. Select an orthogroup to inspect its complete imported protein records.

Marker gene Marker-linked orthogroup

Interpretation

Absence may reflect incomplete assemblies or annotations. Orthogroup membership is supporting evidence only; unannotated orthologues are not automatically promoted to confirmed enzyme calls. Pathway completeness is marker-rule completeness and is not a flux or thermodynamic prediction.